Algonquin College
16.4 - Non-Specific Body Defenses: Surface Barriers
The non-specific defenses or innate defenses are designed to protect the body against different types of pathogens, but not specific pathogens. The non-specific defenses make up the first and second lines of defense in the body.

Surface barriers: First line of defense

The mucosa and the epidermis together line anywhere in our body that is exposed to the external environment. By providing a continuous barrier that separates our internal environment from the outside world, surface barries can prevent pathogens from easily spreading into body tissues.

The surface barriers have several defenses that protect the deeper tissues in the body: