Algonquin College
9.5 - Hypothalamus and Pituitary
Together the hypothalamus and pituitary gland control most of the endocrine functions of the human body.

Hypothalamus

The hypothalamus is a nervous tissue structure immediatley superior to the pituitary gland. It is connected to the pituitary by the hypothalamic pituitary stalk, which contains the axons of neurosecretory neurons and blood vessels of the hypothalamic-hypophyseal portal system.

The neurosecretory neurons of the hypothalamus manufacture two types of hormones: The hypothalamic-hypophyseal portal system is a system of small blood vessels that joins capillary beds in the hypothalamus and anterior pituitary. It carries releasing hormones from the neurosecretory neurons to the gland cells of the anterior pituitary.

Pituitary gland

Also called the hypophysis, the pituitary gland is often called the "master gland" becaues of the number of endocrine and physiological functions it controls.

The pituitary gland consists of two parts: The posterior pituitary (neurophysis) and the anterior pituitary (adenohypophysis). The two parts of the pituitary gland function completely independent of one another, but both are controlled by input from the hypothalamus.

Posterior pituitary gland

The posterior pituitary consists of nervous tissue does not manufacture its own hormones. The hypothalamus manufactures two hormones to be released in the posterior pituitary: Oxytocin and antidiuretic hormone (ADH).

Neurosecretory neurons manufacture oxytocin and ADH.

The hormones travel down the axons of the neurosecretory neurons inside vesicles to the posterior pituitary.

When an action potential arrives at the axon terminals, the hormone vesicles release their contents into the systemic capillaries in the posterior pituitary.

Anterior pituitary gland

The anterior pituitary gland consists of glandular epithelial tissue and manufactures its own hormones.

Releasing hormones travel from the hypothalamus through the hypothalamic-hypohyseal portal system to the anterior pituitary.

The releasing hormones activate specific hormone-producing endocrine cells of the anterior pituitary gland.

The endocrine cells secrete their hormones into the venous systemic circulation.

The anterior pituitary gland produces several hormones: All hormones of the anterior pituitary gland are tropic hormones and stimulate other endocrine glands.

Click here for an digital activity on the hormones of the pituitary gland